A retired detective Tony Zarra (Tony Sirico) is pushed into the world of crime after the murder of his younger brother.

A tale of three women who have reached a turning point in their lives. Delia is a spirited, working-class woman from a small town in New York who leaves her abusive husband and sets out on a journey to reclaim the power she has lost. Greta is a sharp, spunky editor who is rotten with ambition. To spite the hated infidel ways of her father, she has settled into a complacent relationship and is struggling (not too hard) with issues of fidelity to her kind but unexciting husband. Finally Paula, who ran away from home and got pregnant, is now in a relationship she doesn't want. She's a troubled young woman who takes off on a journey with a hitchhiker after a strange, fateful encounter on a New York street.

Eliza Kendall Welch (Uma Thurman), mother of, Clara, and Lucas, lives with her spouse, Avery McKendrik (Anthony Edwards), in an Manhattan apartment. Today is May 25th, Clara's 6th birthday, and she has to make arrangements for a party, as well as attend to day-to-day chores, including Blogging, and entering an online contest 'Motherhood', and looking after her invalid elderly neighbor and a dog. Things will slowly get out of hand after her car gets towed due to a film shooting; the tire on her bike gets punctured; she alienates herself from her friend, Sheila (Minnie Driver); Clara's name is misspelled on the cake; while Avery refuses to answer his cell-phone. After being assisted by a delivery man, Nikesh (Arjun Gupta), who finds her attractive, she concludes she has had enough, and decides not to return home.

New York postal worker Jacob Singer is trying to keep his frayed life from unraveling. His days are increasingly being invaded by flashbacks to his first marriage, his now-dead son, and his tour of duty in Vietnam. Athough his new wife tries to help Jacob keep his grip on sanity, the line between reality and delusion is steadily growing more and more uncertain.

Vincent Lamarca, whose father was executed for a 1950s kidnapping of a child, grew up to become a police officer, only to see his own son become a murderer.

New York. Rebecca (Moore), an actress, is crushed to discover that her marriage may be falling apart. Her husband Tom (Duchovny) leaving long-suffering Rebecca to pick up the pieces of their relationship. Rebecca's brother Tobey (Crudup), meanwhile, is in a long-term relationship with Elaine (Gyllenhaal) that has begun to turn sour. Both couples are spoiled and bratty.